When was rh factor discovered

Blundell J. Experiments on the transfusion of blood by the syringe. Med Chir Trans ; 9 : 56 — Medline Google Scholar. Observations on transfusion of blood.

Lancet — ; 2 : — Bordet JJBV. Ann Inst Pasteur ; 12 : — Landsteiner K. Zur Kenntniss der antifermentativen, lytischen und agglutinierenden Wizkungen des Blutserum und der Lymph.

Zbl Bakt ; 27 : — Decastello A von, Sturli A. Ueber die Isagglutinine im Serum gesunder und kranker Menschen. Agote L. Nuevo procedimiento para la transfusion de la sangre. Ottenberg R. Medicolegal application of human blood grouping.

J Amer Med Assoc ; 77 : — CrossRef Google Scholar. Die Spezifizitat der serologischen Reaktionen. Springer, Berlin You could not be signed in. Sign In Forgot password? Don't have an account? Sign in via your Institution Sign in. Purchase Subscription prices and ordering for this journal Short-term Access To purchase short term access, please sign in to your Oxford Academic account above.

This article is also available for rental through DeepDyve. View Metrics. Email alerts Article activity alert. Advance article alerts. See more Encyclopedia articles on: Anatomy and Physiology. Enter your search terms:. Rh factor, protein substance present in the red blood cells of most people, capable of inducing intense antigenic reactions. The Rh, or rhesus, factor was discovered in by K.

Landsteiner and A. Believing these observations described the same blood group, Landsteiner and Wiener named the Rh blood group after the rhesus macaque.

Scientists have since learned that the Rh blood group antigen described by Levine and Stetson is not the same as the one found in rhesus macaques, and was later named "LW" in honor of Landsteiner and Wiener. The clinical significance of the highly immunogenic RhD antigen was quickly realized, in cases of transfusion and in the diagnosis and prevention of erythroblastosis fetalis commonly called hemolytic disease of the fetus and newborn HDFN.

HDFN is a condition resulting from an incompatibility between the blood types of the mother and her fetus. In cases where an expectant mother is RhD-negative and her fetus is RhD-positive having inherited the RhD antigen from the father, the mother may become exposed to the RhD antigen on fetal red blood cells during delivery.